<?xml version="1.0" encoding="UTF-8"?>

<channelml xmlns="http://morphml.org/channelml/schema"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xmlns:meta="http://morphml.org/metadata/schema"
    xsi:schemaLocation="http://morphml.org/channelml/schema  ../../Schemata/v1.7.3/Level2/ChannelML_v1.7.3.xsd"
    units="Physiological Units">

    <meta:notes>ChannelML file containing a single Channel description</meta:notes>

    <ion name="na" charge="1" default_erev="50"/>  <!-- phys units: mV -->

    <channel_type name="NaChannel" density="yes">
        
        <status value="deprecated">
            <meta:comment>This form of ChannelML (with ohmic and hh_gate elements) should no longer be used. See NaChannel_HH.xml instead.</meta:comment>
            <meta:contributor>
                <meta:name>Padraig Gleeson</meta:name>
            </meta:contributor>
        </status>

        <meta:notes>Simple example of Na conductance in squid giant axon. Based on channel from Hodgkin and Huxley 1952</meta:notes>
        
        <meta:authorList>
            <meta:modelTranslator>
                <meta:name>Padraig Gleeson</meta:name>
                <meta:institution>UCL</meta:institution>    
                <meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            </meta:modelTranslator>
        </meta:authorList>

        <meta:publication>
            <meta:fullTitle>A. L. Hodgkin and A. F. Huxley, A quantitative description of membrane current and
            its application to conduction and excitation in nerve, J. Physiol., vol. 117, pp. 500-544, 1952.</meta:fullTitle>
            <meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=12991237</meta:pubmedRef>
        </meta:publication>

        <meta:neuronDBref>
            <meta:modelName>Na channels</meta:modelName>
            <meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table2</meta:uri>
        </meta:neuronDBref>


        <current_voltage_relation>
            <ohmic ion="na">
                <conductance default_gmax="120"> <!-- phys units: mS/cm2 -->
                    <gate power="3">
                        <state name="m" fraction="1"/>
                    </gate>
                    <gate power="1">
                        <state name="h" fraction="1"/>
                    </gate>
                </conductance>
            </ohmic>
        </current_voltage_relation>
        
        
        <hh_gate state="m">
            <transition>
                <voltage_gate>
                    <alpha>
                        <parameterised_hh type="linoid" > <!-- Form of equation: A*(k*(v-d)) / (1 - exp(-(k*(v-d)))) -->
                            <parameter name="A" value="1"/>
                            <parameter name="k" value="0.1"/>
                            <parameter name="d" value="-40"/>
                        </parameterised_hh>
                    </alpha>
                    <beta>
                        <parameterised_hh type="exponential">  <!-- Form of equation: A*exp(k*(v-d)) -->
                            <parameter name="A" value="4"/>
                            <parameter name="k" value="-0.0555555555"/>
                            <parameter name="d" value="-65"/>
                        </parameterised_hh>
                    </beta>
                </voltage_gate>
            </transition>
        </hh_gate>
        
        <hh_gate state="h">
            <transition>
                <voltage_gate>
                    <alpha>
                        <parameterised_hh type="exponential">  <!-- Form of equation: A*exp(k*(v-d)) -->
                            <parameter name="A" value="0.07"/>
                            <parameter name="k" value="-0.05"/>
                            <parameter name="d" value="-65"/>
                        </parameterised_hh>
                    </alpha>
                    <beta>
                        <parameterised_hh type="sigmoid">  <!-- Form of equation: A / (1 + exp(k*(v-d))) -->
                            <parameter name="A" value="1"/>
                            <parameter name="k" value="-0.1"/>
                            <parameter name="d" value="-35"/>
                        </parameterised_hh>
                    </beta>
                </voltage_gate>
            </transition>
        </hh_gate>
        
        
    </channel_type>
</channelml>